Personalis is a genome-scale diagnostics company pioneering genome guided medicine. Personalis Genome Services provides clinicians and researchers accurate comprehensive end-to-end human genome sequencing and interpretation solutions in Mendelian disease, cancer, and pharmacogenomics. We provide accuracy enhanced genome sequencing assays, conducted in our state-of-the art laboratory.  We analyze results utilizing proprietary databases, advanced human reference sequences, and sophisticated algorithms.  Located in Menlo Park, CA, we are seeking a talented and highly motivated Bioinformatics Engineer to join our Team. 

RESPONSIBILITIES:

• Manipulate large next generation sequencing datasets in Unix/Linux environment.
• Manage daily data production from samples run through our services laboratory.
• Assist in maintenance of our LIMS system by optimizing the API commands and integrating with other internal systems.
• Develop high throughput solutions to improve scalability of in house developed genetic interpretation tools.
• Implement internally developed analysis systems, as well as support new applications development.
• Provide bioinformatics support to ensure data quality and usability. 
• Prepare data packaging for delivery of datasets to customers.
• Participate in both internal research projects and external research collaborations.
• Contribute to the development of innovative data management/integration and information intelligence solutions.
• Act as bridge between end users and developers to clarify and define system requirements.
• Perform data mining to extract maximal value out of information system.
• Maintain expertise in state-of-the-art bioinformatics methods.
• Proactively communicate to key stakeholders of activities and status.

POSITION REQUIREMENTS:

• Proficient in common bioinformatics databases and tools; can independently design and perform diverse bioinformatics tasks
• Demonstrated expertise in at least one programming language (Java, Perl, Python, etc.), proficiency in Linux environment, knowledge of database technologies (SQL Server, Oracle, MongoDB), understanding of web services technologies, experience with source control practices and tools (Perforce, Git, etc.)
• Deep knowledge of both academic and commercial informatics solutions
• Excellent interpersonal skills with a proven record of collaborating with teams of research scientists, bioinformaticians, software developers, and external collaborators
• Experience with High performance computing, SGE environment, large scale NAS, cloud computing a plus
• Excellent analytical, mathematical and quantitative problem solving skills
• Solid understanding of data modeling tools/packages, such as R, Matlab, or equivalent
• Project management experience and software development practices is desirable
• Strong desire to work in a demanding, high-energy, hands-on startup environment
• Strong commitment to customer service

EDUCATION/EXPERIENCE:

• Advanced degree in Bioinformatics, Genomics, Computer Science, Systems Biology or equivalent with a focus on data analysis.
• 3+ years of industry (or research institute) experience in computational genomics; proficiency in large volume data analysis
• 3+ years experience with diverse types of genomics data and proficient in genomics data analysis tools/packages such as BWA and GATK
• An interest in cancer biology, genetics and infectious diseases, and the ability and desire to interact with scientists from various backgrounds

Personalis is an equal opportunity employer. Personalis offers a competitive compensation package. If interested, please submit a letter of interest, resume and salary requirements to careers @ personalis.com.